Phone: 212-241-0746 Fax: 212-860-369 E-mail: steven.rosen@mssm.edu Mount Sinai School of Medicine Box 1065, One Gustave L. Levy Place, New York, NY 10029

Research:

The study of cellular mechanisms underlying motivational and/or behavioral states, including hunger and satiety in the mollusk Aplysia, has been advanced by the identification of pattern initiating or command-like neurons for feeding. Command-like neurons come in a variety of flavors and the feeding pattern generating network that they affect produces a variety of motor outputs. Limited understanding of motor output variability has emerged as an obstacle to further progress. Currently we are examining the hypothesis that feeding behavior is more complex than formerly appreciated and that unexplained variations of the underlying neuronal activity of the CNS might reflect subtle and important behavioral differences that have hitherto escaped detection. We study Aplysia ingestion using digital video techniques that permit a kinematics analysis of the behavior. Early findings indicate that Aplysia feeding is capable of adaptive change appropriate to different characteristics of edible seaweed species that are available. The changes are subtle, but nonetheless significant and suggest that Aplysia feed in qualitatively different modes, each requiring a different configuration of the underlying pattern generating network.

Selected Publications:

Cropper EC, Evans CG, Hurwitz I, Jing J, Proekt A, Romero A, Rosen SC. Feeding neural networks in the mollusc Aplysia. Neurosignals. 2004 Jan-Apr;13(1-2):70-86. Read as PDF

Cropper EC, Evans CG, Jing J, Klein A, Proekt A, Romero A, Rosen SC. Regulation of afferent transmission in the feeding circuitry of Aplysia. Acta Biologica Hungarica 55 (1-4) :211-220 (2004) Read as PDF

Evans CG, Jing J, Proekt A, Rosen SC, Cropper E. Frequency-dependent regulation of afferent transmission in the feeding circuitry of Aplysia. J Neurophysiol. 2003 Sep 24 [Epub ahead of print] Read as PDF

Evans CG, Jing J, Rosen SC, Cropper EC. Regulation of spike initiation and propagation in an Aplysia sensory neuron: gating-in via central depolarization. J Neurosci. 2003 Apr 1;23(7):2920-31. Read as PDF

Rosen SC, Miller MW, Cropper EC, Kupfermann I. Outputs of radula mechanoafferent neurons in Aplysia are modulated by motor neurons, interneurons, and sensory neurons. J Neurophysiol. 2000 Mar;83(3):1621-36. Read as PDF

Rosen SC, Miller MW, Evans CG, Cropper EC, Kupfermann I. Diverse synaptic connections between peptidergic radula mechanoafferent neurons and neurons in the feeding system of Aplysia. J Neurophysiol. 2000 Mar;83(3):1605-20. Read as PDF

Borovikov D, Evans CG, Jing J, Rosen SC, Cropper EC. A proprioceptive role for an exteroceptive mechanoafferent neuron in Aplysia. J Neurosci. 2000 Mar 1;20(5):1990-2002. Read as PDF

Alexeeva V, Borovikov D, Miller MW, Rosen SC, Cropper EC. Effect of a serotonergic extrinsic modulatory neuron (MCC) on radula mechanoafferent function in Aplysia. J Neurophysiol. 1998 Oct;80(4):1609-22. Read as PDF

Susswein AJ, Rosen SC, Gapon S, Kupfermann I. Characterization of buccal motor programs elicited by a cholinergic agonist applied to the cerebral ganglion of Aplysia californica. J Comp Physiol [A]. 1996 Oct;179(4):509-24.

Cropper EC, Evans CG, Rosen SC. Multiple mechanisms for peripheral activation of the peptide-containing radula mechanoafferent neurons B21 and B22 of Aplysia. J Neurophysiol. 1996 Aug;76(2):1344-51.

Miller MW, Rosen SC, Schissel SL, Cropper EC, Kupfermann I, Weiss KR. A population of SCP-containing neurons in the buccal ganglion of Aplysia are radula mechanoafferents and receive excitation of central origin. J Neurosci. 1994 Nov;14(11 Pt 2):7008-23.

Vilim FS, Cropper EC, Rosen SC, Tenenbaum R, Kupfermann I, Weiss KR. Structure, localization, and action of buccalin B: a bioactive peptide from Aplysia. Peptides. 1994;15(6):959-69.

Teyke T, Rosen SC, Weiss KR, Kupfermann I Dopaminergic neuron B20 generates rhythmic neuronal activity in the feeding motor circuitry of Aplysia. Brain Res. 1993 Dec 10;630(1-2):226-37.

Weiss KR, Brezina V, Cropper EC, Heierhorst J, Hooper SL, Probst WC, Rosen SC, Vilim FS, Kupfermann I. Physiology and biochemistry of peptidergic cotransmission in Aplysia. J Physiol Paris. 1993;87(3):141-51. Review. Read as PDF

Kupfermann I, Deodhar D, Teyke T, Rosen SC, Nagahama T, Weiss KR. Behavioral switching of biting and of directed head turning in Aplysia: explorations using neural network models. Acta Biol Hung. 1992;43(1-4):315-28. Review. No abstract available.

Rosen SC, Teyke T, Miller MW, Weiss KR, Kupfermann I. Identification and characterization of cerebral-to-buccal interneurons implicated in the control of motor programs associated with feeding in Aplysia. J Neurosci. 1991 Nov;11(11):3630-55.

Rosen SC, Weiss KR, Goldstein RS, Kupfermann I. The role of a modulatory neuron in feeding and satiation in Aplysia: effects of lesioning of the serotonergic metacerebral cells. J Neurosci. 1989 May;9(5):1562-78.

Weiss KR, Bayley H, Lloyd PE, Tenenbaum R, Kolks MA, Buck L, Cropper EC, Rosen SC, Kupfermann I. Purification and sequencing of neuropeptides contained in neuron R15 of Aplysia californica. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2913-7.

Rosen SC, Susswein AJ, Cropper EC, Weiss KR, Kupfermann I. Selective modulation of spike duration by serotonin and the neuropeptides, FMRFamide, SCPB, buccalin and myomodulin in different classes of mechanoafferent neurons in the cerebral ganglion of Aplysia. J Neurosci. 1989 Feb;9(2):390-402.

Rosen SC, Kupfermann I, Goldstein RS, Weiss KR. Lesion of a serotonergic modulatory neuron in Aplysia produces a specific defect in feeding behavior. Brain Res. 1983 Jan 31;260(1):151-5.

Rosen SC, Weiss KR, Cohen JL, Kupfermann I. Interganglionic cerebral-buccal mechanoafferents of Aplysia: receptive fields and synaptic connections to different classes of neurons involved in feeding behavior. J Neurophysiol. 1982 Jul;48(1):271-88. No abstract available.

Rosen SC, Weiss KR, Kupfermann I. Cross-modality sensory integration in the control of feeding Aplysia. Behav Neural Biol. 1982 May;35(1):56-63. No abstract available.

Rosen SC, Weiss KR, Kupfermann I. Response properties and synaptic connections of mechanoafferent neurons in cerebral ganglion of Aplysia. J Neurophysiol. 1979 Jul;42(4):954-74.

Sandrew BB, Stamm JS, Rosen SC. Steady potential shifts and facilitated learning of delayed response in monkeys. Exp Neurol. 1977 Apr;55(1):43-55. No abstract available.

Stamm JS, Gadotti A, Rosen SC. Interhemispheric functional differences in prefrontal cortex of monkeys. J Neurobiol. 1975 Jan;6(1):39-49.

Rosen SC, Stamm JS. Transcortical polarization: facilitation of delayed response performance by monkeys. Exp Neurol. 1972 May;35(2):282-9. No abstract available.

Stamm JS, Rosen SC. Cortical steady potential shifts and anodal polarization during delayed response performance. Acta Neurobiol Exp (Wars). 1972;32(2):193-209. No abstract available.

Stamm JS, Rosen SC. Learning on somesthetic discrimination and reversal tasks by monkeys with epileptogenic implants in anteromedial temporal cortex. Neuropsychologia. 1971 Jun;9(2):185-94. No abstract available.

Rosen SC, Stamm JS. Cortical steady potential shifts during delayed response performance by monkeys. Electroencephalogr Clin Neurophysiol. 1969 Sep;27(7):684-5. No abstract available.

Stamm JS, Rosen SC. Electrical stimulation and steady potential shifts in prefrontal cortex during delayed response performance by monkeys. Acta Biol Exp (Warsz). 1969;29(3):385-99. No abstract available.

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