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Phone: 212-241-0212 Fax: 212-860-3369 or E-mail: elizabeth.cropper@mssm.edu
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Research
Selected Projects
Selected Publications
Elizabeth Cropper institutional webpage
Motor behaviors are often mediated by central pattern generators (CPGs) that can generate rhythmic output without afferent input. Physiologically, however, CPGs often receive sensory information so that activity is adjusted to compensate for changes in the periphery. When this occurs, changes in motor output are not always solely determined by stimulus properties. Instead peripherally and centrally generated activity can be integrated so that stimulus-induced changes in motor output depend on the state of the ongoing motor program. Thus, afferent transmission can be regulated (i.e., gated) during rhythmic activity. Current experiments in our laboratory seek to determine how sensory and motor activity is integrated during feeding behavior in the marine mollusc Aplysia calfornica.
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The importance of afferent input during feeding motor programs in Aplysia |
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Sensori-motor integration during rhythmic activity; Regulation of spike propagation in the radula mechanoafferent B21 |
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Central depolarization potentiates afferent transmission |
Synaptic input can exert inhibitory effects on radula mechanoafferent transmission |
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Morphological studies of sensory neurons |
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Quicktime movie of the rotation of the tip of the lateral process of B21 |
A part of the lateral process of B21 |
Evans CG, Romero A, Cropper
EC, Inhibition of afferent transmission in the feeding circuitry of
Aplysia: Persistence can be as important as size. J Neurophysiol. 2004
Dec 29;[Epub ahead of print] Read as PDF |
| Shetreat-Klein AN, Cropper
EC.
Afferent-induced changes in rhythmic motor programs in the feeding
circuitry of Aplysia. J Neurophysiol. 2004 Oct;92(4):2312-22. Epub 2004
Jun 02. Read as PDF |
| Jing J, Cropper EC, Hurwitz I, Weiss KR.
The construction of movement with behavior-specific and
behavior-independent modules.
J Neurosci. 2004 July 14;24(28):6315-25. Read as PDF |
| Cropper EC, Evans CG, Hurwitz I, Jing J, Proekt
A, Romero A, Rosen SC.
Feeding neural networks in the mollusc Aplysia.
Neurosignals. 2004 Jan-Apr;13(1-2):70-86. Read as PDF |
| Cropper EC, Evans CG, Jing J, Klein A, Proekt A,
Romero A, Rosen SC.
Regulation of afferent transmission in the feeding circuitry of
Aplysia.
Acta Biologica Hungarica 55 (1-4) :211-220 (2004) Read as PDF |
| Evans CG, Jing J, Proekt A, Rosen SC, Cropper E.
Frequency-dependent regulation of afferent transmission in the feeding
circuitry of Aplysia.
J Neurophysiol. 2003 Dec;90(6):3967-77.Epub 2003 Sep 24. Read as PDF |
| Dembrow NC, Jing J, Proekt A, Romero A, Vilim FS, Cropper
EC, Weiss KR.
A newly identified buccal interneuron initiates and modulates feeding
motor programs in Aplysia.
J Neurophysiol. 2003 Oct;90(4):2190-204.Epub 2003 Jun 11. Read as PDF |
| Evans CG, Jing J, Rosen SC, Cropper EC.
Regulation of spike initiation and propagation in an Aplysia sensory
neuron: gating-in via central depolarization.
J Neurosci. 2003 Apr 1;23(7):2920-31. Read as PDF |
| Furukawa Y, Nakamaru K, Wakayama H, Fujisawa Y,
Minakata H, Ohta S, Morishita F, Matsushima O, Li L, Romanova E,
Sweedler JV, Park JH, Romero A, Cropper EC, Dembrow NC, Jing J,
Weiss KR, Vilim FS. The enterins: a novel family of neuropeptides
isolated from the enteric nervous system and CNS of Aplysia.
J Neurosci. 2001 Oct 15;21(20):8247-61. Read as PDF |
| Orekhova IV, Jing J, Brezina V, DiCaprio RA, Weiss KR, Cropper
EC. Sonometric measurements of motor-neuron-evoked movements of an
internal feeding structure (the radula) in Aplysia.
J Neurophysiol. 2001 Aug;86(2):1057-61. Read as PDF |
| Klein AN, Weiss K, Cropper EC.
Glutamate is the fast excitatory neurotransmitter of small cardioactive
peptide-containing Aplysia radula mechanoafferent neuron B21.
Neurosci Lett
2000 Jul 28;289(1):37-40. |
| Vilim F, Cropper EC, Price DA,
Kupfermann I, Weiss K. Peptide cotransmitter release from
motorneuron B16 in aplysia californica: costorage, corelease, and
functional implications.
J Neurosci
2000 Mar 1;20(5):2036-42. Read as PDF |
| Rosen SC, Miller MW, Cropper EC,
Kupfermann I. Outputs of radula mechanoafferent neurons in Aplysia
are modulated by motor neurons, interneurons, and sensory neurons.
J Neurophysiol
2000 Mar;83(3):1621-36. Read as PDF |
| Rosen SC, Miller MW, Evans C, Cropper
EC, Kupfermann I. Diverse synaptic connections between
peptidergic radula mechanoafferent neurons and neurons in the feeding
system of Aplysia.
J Neurophysiol
2000 Mar;83(3):1605-20. Read as PDF |
| Borovikov D, Evans C, Jing J,
Rosen SC, Cropper EC. A proprioceptive role for an
exteroceptive mechanoafferent neuron in Aplysia.
J Neurosci
2000 Mar 1;20(5):1990-2002. Read as PDF |
| Evans C, Vilim F, Harish O,
Kupfermann I, Weiss K, Cropper EC. Modulation of
radula opener muscles in Aplysia.
J Neurophysiol
1999 Sep;82(3):1339-51. Read as PDF |
| Evans C, Alexeeva V, Rybak J,
Karhunen T, Weiss K, Cropper EC. A pair of
reciprocally inhibitory histaminergic sensory neurons are activated
within the same phase of ingestive motor programs in Aplysia.
J Neurosci
1999 Jan 15;19(2):845-58. Read as PDF |
| Alexeeva V, Borovikov D, Miller M,
Rosen SC, Cropper EC. Effect of a serotonergic extrinsic
modulatory neuron (MCC) on radula mechanoafferent function in Aplysia.
J Neurophysiol
1998 Oct;80(4):1609-22. Read as PDF |
| Evans C, Cropper EC. Proprioceptive input
to feeding motor programs in Aplysia.
J Neurosci
1998 Oct 1;18(19):8016-31. Read as PDF |